PUBLICATIONS
Platform Development

A Clinical System For Non-Invasive Blood Brain Barrier Opening Using A Neuronavigation-Guided Single-Element Focused Ultrasound Transducer.

Antonios N. Pouliopoulos, Shih-Ying Wu, Mark T. Burgess, Maria Eleni Karakatsani, Hermes A.S. Kamimura, and Elisa E. Konofagou. Ultrasound in Med & Biol. 2019. 0(0): 1-17.

Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates.

Antonios N. Pouliopoulos, Nancy Kwon, Greg Jensen, Anna Meaney, Yusuke Niimi, Mark T. Burgess, Robin Ji, Alicia J. McLuckie, Fabian A. Munoz, Hermes A. S. Kamimura, Andrew F. Teich, Vincent P. Ferrera, and Elisa E. Konofagou. Sci Rep. 2021 Jul 22; 11(1):15043.

Targeting Effects on the Volume of the Focused Ultrasound-Induced Blood-Brain Barrier Opening in Nonhuman Primates In Vivo.

Maria Eleni Marilena Karakatsani, Gesthimani Mania Samiotaki, Matthew E Downs, Vincent P Ferrera, Elisa E Konofagou. IEEE Trans Ultrason Ferroelectr Freq Control. 2017 May; 64(5): 798–810.

Characterizing Focused-Ultrasound Mediated Drug Delivery to the Heterogeneous Primate Brain In Vivo with Acoustic Monitoring.

Wu SY, Sanchez CS, Samiotaki G, Buch A, Ferrera VP, Konofagou EE. Sci Rep. 2016 Nov 17;6:37094.

Efficient Blood-Brain Barrier Opening in Primates with Neuronavigation-Guided Ultrasound and Real-Time Acoustic Mapping.

Shih-Ying Wu, Christian Aurup, Carlos Sierra Sanchez, Julien Grondin, Wenlan Zheng, Hermes Kamimura, Vincent P Ferrera, Elisa E Konofagou. Sci Rep. 2018 May 22;8(1):7978.

Real-time passive acoustic mapping using sparse matrix multiplication.

Hermes A. S. Kamimura, Shih-Ying Wu, Julien Grondin, Robin Ji, Christian Aurup, Wenlan Zheng, Marc Heidmann, Antonios N. Pouliopoulos, and Elisa Konofagou. IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Jan; 68(1): 164–177

Power cavitation-guided blood-brain barrier opening with focused ultrasound and microbubbles.

M T Burgess, I Apostolakis, E E Konofagou. Phys Med Biol. 2018 Mar; 63(6).

Columbia BME’s own, Elisa Konofagou, uses focused ultrasound to non-invasively open the blood-brain-barrier to deliver drugs and apply gene therapy.

A Clinical System For Non-Invasive Blood Brain Barrier Opening Using A Neuronavigation-Guided Single-Element Focused Ultrasound Transducer.

Antonios N. Pouliopoulos, Shih-Ying Wu, Mark T. Burgess, Maria Eleni Karakatsani, Hermes A.S. Kamimura, and Elisa E. Konofagou. Ultrasound in Med & Biol. 2019. 0(0): 1-17.

Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates.

Targeting Effects on the Volume of the Focused Ultrasound-Induced Blood-Brain Barrier Opening in Nonhuman Primates In Vivo.

Maria Eleni Marilena Karakatsani, Gesthimani Mania Samiotaki, Matthew E Downs, Vincent P Ferrera, Elisa E Konofagou. IEEE Trans Ultrason Ferroelectr Freq Control. 2017 May; 64(5): 798–810.

Characterizing Focused-Ultrasound Mediated Drug Delivery to the Heterogeneous Primate Brain In Vivo with Acoustic Monitoring.

Wu SY, Sanchez CS, Samiotaki G, Buch A, Ferrera VP, Konofagou EE. Sci Rep. 2016 Nov 17;6:37094.

Efficient Blood-Brain Barrier Opening in Primates with Neuronavigation-Guided Ultrasound and Real-Time Acoustic Mapping.

Shih-Ying Wu, Christian Aurup, Carlos Sierra Sanchez, Julien Grondin, Wenlan Zheng, Hermes Kamimura, Vincent P Ferrera, Elisa E Konofagou. Sci Rep. 2018 May 22;8(1):7978.

Real-time passive acoustic mapping using sparse matrix multiplication.

Power cavitation-guided blood-brain barrier opening with focused ultrasound and microbubbles.

M T Burgess, I Apostolakis, E E Konofagou. Phys Med Biol. 2018 Mar; 63(6).

Columbia BME’s own, Elisa Konofagou, uses focused ultrasound to non-invasively open the blood-brain-barrier to deliver drugs and apply gene therapy.

Optimization of the Ultrasound-Induced Blood-Brain Barrier Opening.

Elisa E. Konofagou. Theranostics. 2012;2(12):1223-37.

Focused ultrasound mediated blood–brain barrier opening is safe and feasible in a murine pontine glioma model.

Zachary K. Englander, Hong-Jian Wei, Antonios N. Pouliopoulos, Ethan Bendau, Pavan Upadhyayula, Chia-Ing Jan, Eleanora F. Spinazzi, NinaYoh, Masih Tazhibi, Nicholas M. McQuillan, Tony J. C. Wang, Jefrey N. Bruce, Peter Canoll, Neil A. Feldstein, Stergios Zacharoulis, Elisa E. Konofagou & Cheng-Chia Wu. Nature Sci Reports. 2021. 11:6521.

Focused Ultrasound-Mediated Blood-Brain Barrier Opening Increases Delivery and Efficacy of Etoposide for Glioblastoma Treatment.

Hong-Jian Wei, PhD, Pavan S. Upadhyayula, Antonios N. Pouliopoulos, Zachary K. Englander, Xu Zhang, Chia-Ing Jan, Jia Guo, Angeliki Mela, Zhiguo Zhang, Tony J.C. Wang, Jeffrey N. Bruce, Peter D. Canoll, Neil A. Feldstein, Stergios Zacharoulis, MD, Elisa E. Konofagou, and Cheng-Chia Wu. Int J Radiation Oncol Biol Phys. 2020.

Amelioration of the nigrostriatal pathway facilitated by ultrasound-mediated neurotrophic delivery in early Parkinson’s disease.

Wang, Gesthimani Samiotaki, Tara Kugelman, Oluyemi O. Olumolade, Camilo Acosta, Tao Sun, Yang Han, Hermes A.S., Kamimura, Vernice Jackson-Lewis, Serge Przedborski, Elisa Konofagou. J Control Release. 2019 Jun 10(303):289-301.

Unilateral Focused Ultrasound-Induced Blood-Brain Barrier Opening Reduces Phosphorylated Tau from The rTg4510 Mouse Model.

Maria Eleni Karakatsani, Tara Kugelman, Robin Ji, Maria Murillo, Shutao Wang, Yusuke Niimi, Scott A Small, Karen E Duff, and Elisa E Konofagou. Theranostics. 2019 Jul 13;9(18):5396-5411.

Non-invasive, Focused Ultrasound-Facilitated Gene Delivery for Optogenetics.

Wang Shutao, Amanda Buch, Camilo Acosta, Oluyemi Olumolade, Syed, H, Duff K, Elisa Konofagou. Sci Rep. 2017 Jan 6;7:39955.

Focused ultrasound-mediated brain genome editing.

Yeh-Hsing Lao, Robin Ji, Joyce K. Zhou, Kathy J. Snow, Nancy Kwon, Ethan Saville, Siyu He, Shradha Chauhan, Chun-Wei Chi, Malika S. Datta, Hairong Zhang, Chai Hoon Quek, Sarah Cai, Mingqiang Li, Yaned Gaitan, Lawrence Bechtel, Shih-Ying Wu, Cathleen M. Lutz, Raju Tomer, Stephen A. Murray, Alejandro Chavez, Elisa E. Konofagou, Kam W. Leong. bioRxiv 2022.12.10.519924.